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Additional aid and checking can be needed when prescribing for clients susceptible to opioid misuse.Monitor Carefully (one)mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Mitotane is a solid inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates f